NOT KNOWN FACTS ABOUT PROLEVIATE CONOLIDINE BENEFITS PATIENTS

Preliminary research suggest conolidine may possibly inhibit precise ion channels, lessening neuronal excitability and limiting discomfort signals. This mechanism is particularly relevant in neuropathic pain, in which irregular signaling causes persistent irritation. Furthermore, conolidine seems to impact G protein-coupled receptor (GPCR) pathways

Whilst the opiate receptor relies on G protein coupling for signal transduction, this receptor was observed to use arrestin activation for internalization of the receptor. In any other case, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable enhancement in binding efficacy. This bind